| abstract |
The invention relates to anti-PD-1 antibodies or fragments thereof. According to various examples, the antibodies or fragments thereof comprise heavy chain variable regions comprising heavy chain complementarity determining regions HCDR1 (SEQ ID NO: 1, 7 or 13), HCDR2 (SEQ ID NO: 2, 8 or 14). ), and HCDR3 (SEQ ID NO: 3, 9 or 15), and light chain variable regions comprising light chain complementarity determining regions LCDR1 (SEQ ID NO: 4, 10 or 16), LCDR2 (SEQ ID NO: 5, 11 or 17), and LCDR3 (SEQ ID NO: 6, 12 or 18). The invention also relates to methods of using antibodies or fragments thereof for the treatment and diagnosis of diseases such as cancer, infection or immune disorders. |