| abstract |
Disclosed in the present invention are a farnesoid X receptor (FXR) agonist compound and a preparation method and use therefor. Specifically, provided in the present invention are a heterocyclic FXR agonist compound, as well as stereoisomers, a tautomer, a polymorph, a solvate (e.g., a hydrate), a pharmaceutically acceptable salt, an ester, a metabolite and an N-oxide thereof, and a chemically protected form and a prodrug of the foregoing. The present invention also provides a method for preparing the compound and a pharmaceutical composition and a kit which contain the compound, as well as a use therefor in the treatment of diseases or conditions which are mediated by FXR. |