| abstract |
A drug delivery system and methods of using such for delivering a PEGylated therapeutic agent to brain. The drug delivery system may comprise an antibody, which binds polyethylene glycol (PEG), wherein the antibody is embedded in a hydrogel, which may comprise one or more biodegradable polymers, up to 60 % of which contain inter-chain or intra-chain covalent crosslinks. The amount of the antibody in the drug delivery system can be about 1-2 g per l of the hydrogel. |