| abstract |
Provided is a medicinal composition to be used for treating an intractable heart tissue fibrosis disease accompanying chronic heart failure. The medicinal composition, which is to be used for treating an intractable heart tissue fibrosis disease accompanying chronic heart failure, comprises as an active ingredient at least one member selected from the group consisting of a protease inhibitor, a thromboxane A2 synthase inhibitor and an antagonist thereof, a phosphodiesterase (PDE) inhibitor, a tyrosine kinase inhibitor, an HMG-CoA reductase inhibitor and an anti-fibrosis agent. (Said medicinal composition includes a sustainable preparation thereof enclosed in a biodegradable polymer.) |