| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_11b6b43c7d7f4b33377f6b7a7b4250e6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3181
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-18001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y113-11052 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2017-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5be3a15d17426800d3fbe2838a6b10e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_494dd04b35b0feef129d3f6dad89af3c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a40da60c0cb7c78348939ca3080399e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32522e4aad6cbcd8614d96902c7cc9cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87f33a8c3933c39704c8d63482d52704 |
| publicationDate |
2018-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018122610-A1 |
| titleOfInvention |
Exon skipping by peptide nucleic acid derivatives |
| abstract |
A peptide nucleic acid derivative of Formula (I) is provided to tightly bind to a splice site withiun a pre-mRNA in a sequence specific manner. Given with excellent cell membrane permeability and strong affinity for RNA, the said peptide nucleic acid derivative induces exon skipping in cells treated with the peptide nucleic acid at sub-femtomolar concentration as "naked" oligonucleotide. The said compound shows therapeutic activity in subjects upon systemic administration even at 1 μg/Kg or less, and therefore is useful to treat a disease or symptom at affordable treatment cost. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019022434-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021010723-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11162104-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3565825-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3573998-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3497114-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3837274-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11261448-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020157760-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739124-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022084389-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2018308224-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2018308224-B9 |
| priorityDate |
2016-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |