| abstract |
The invention discloses a nitrogen-containing fused heterocyclic compound, a preparation method therefor, and an intermediate, a composition, and an application thereof. The compound of the present invention has a high inhibitory activity against different subtypes of CDK at the molecular level, has a desirable inhibitory activity against breast cancer cells at the cellular level, and also has a significant proliferation-inhibiting effect on tumor cells associated with the activity of a cyclin-dependent kinase at the animal level. Moreover, the compound has a good stability with respect to liver microsomes of humans and mice, has no significant inhibition of metabolic enzymes, and has a good absorption in rats and mice, a high bioavailability, and a good druggability. |