Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e3ae86ccb3f590dda203f386edfd63a9 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0634 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0646 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17 |
filingDate |
2017-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d858e6eb980ba70f16a7643cd06a1b3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ce9c1e72f0de8b6ff065513b0a4fce0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19621ba77ba9864124d8f1ccc528fe67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96d81d1365342eb9272ec79503ee46a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_536fc69ae1be4455f239a7d6d4c63c1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_687c2799d0ae747498609815895c354b |
publicationDate |
2018-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2018121604-A1 |
titleOfInvention |
Multi-target chimeric antigen receptor |
abstract |
Disclosed in the present invention is a multi-target chimeric antigen receptor. Provided in the present invention is a multi-target chimeric antigen receptor consisting of a main peptide chain and an auxiliary peptide chain; the main peptide chain comprises an antigen binding domain A, an auxiliary peptide chain connecting domain B, a transmembrane domain C and an intracellular signaling domain D; the auxiliary peptide chain comprises a main peptide chain connecting domain F; the antigen binding domain A is a polypeptide having an antigen-binding function; the auxiliary chain connecting domain B and the main peptide connecting domain F are combined with each other; the transmembrane domain C is a transmembrane domain of any membrane-binding protein or a transmembrane protein; and the intracellular signaling domain D comprises a primary signaling region. The multi-target chimeric antigen receptor of the present invention can bind to different antigens through the two antigen binding domains thereof, and mediates specific cell killing; and a cytokine and cytokine receptor complex playing the role of a cytokine are introduced into the multi-target chimeric antigen receptor of the present invention. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113493524-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112877346-A |
priorityDate |
2016-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |