abstract |
Provided are a trifunctional molecule and an application thereof. The structure of the trifunctional molecule comprises a first functional domain, a second functional domain and a third functional domain therein, which may simultaneously bind CD19, CD3, and a positive (negative) co-stimulating factor of a T cell, thereby producing a first signal and a second signal which are needed for T cell activation, and further enhancing the effect of activating T cells while imparting T cells with a CD19 positive cell targeting property. The trifunctional molecule is a recombinant protein peptide chain which may be produced by using a eukaryotic cell expression system. |