| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1241
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-36 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-207
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-81 |
| filingDate |
2017-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5a5345937dda3fa769672a95c6fa698
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04302d97b9d20f74f0e1f50cf698bc1f |
| publicationDate |
2018-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018119117-A1 |
| titleOfInvention |
Methods of producing cyclic dinucleotides |
| abstract |
The present disclosure provides cyclic dinucleotides (CDNs), and methods of preparing and using the same. The subject methods can include contacting a CDN producing-enzyme with a precursor of a CDN under conditions sufficient to convert the precursor into a CDN. In some embodiments, the CDN producing-enzyme is a Hypr GGDEF enzyme. The methods can be performed in vitro or in a genetically modified host cell. Also provided are CDN compositions that find use in a variety of applications. Methods of modulating an immune response in an individual and methods of inhibiting a bacterial biofilm in an industrial system are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11725024-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2022500476-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11787833-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11492367-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7218431-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11666594-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11542293-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2019344398-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11400108-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10980825-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020057546-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11299512-B2 |
| priorityDate |
2016-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |