http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018115078-A1

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publicationDate 2018-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018115078-A1
titleOfInvention Detecting an analyte in a flash and glow reaction
abstract Accurate measurements of the presence or absence of a target cell in a sample are provided. For example, the sample can be mixed with a plurality of transduction particles capable of binding to the target cells, the transduction particles being engineered to include a nucleic acid molecule formulated to cause the target cells to produce a plurality of detectable reporter molecules once the particles bind to and deliver the nucleic acid molecules into the one or more target cells. A set of signal data points are received that are associated with a quantity of reporter molecules and the signal data points are analyzed to accurately detect target cells in the sample. A curve is generated from the data gathered and analysed for peaks, which are mathematically transformed into positive signal data points using Area ratio, relative variation of the relative light units (RLU) and a linear threshold. Systems and methods are disclosed.
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