http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018113710-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bffe926681f73580c63f8bbeff581d9f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2017-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_706e954022e16d611cb3c7db311c3cb9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f903ff5f6cf385ffd8b209c97cf630a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6450a260fb62cb2a9723682123b92df9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8738ed7841ab9863e02326bb2d3c2d42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87ba518aaaa1cbb54cc479926ea1a410 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a7e4ca4e3d426130d1b6426a60abcb4 |
| publicationDate | 2018-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2018113710-A1 |
| titleOfInvention | METHOD FOR PREPARING β-NUCLEOSIDE COMPOUND |
| abstract | Provided in the present invention is a method for preparing a β -nucleoside compound, comprising the steps of: 1) performing a silylation reaction of a nitrogenous base or an analogue thereof in the presence of TMSOTf to obtain the nitrogenous base or the analogue thereof being protected by trimethylsilyl; 2) performing a direct glycosylation reaction of the reaction liquid, without being isolated, and a five- or six-membered ring saccharide or a derivative thereof closed by a hydroxy protecting group to obtain a closed β -nucleoside compound; and 3) performing a deprotection reaction to obtain the β -nucleoside compound. The method uses a one-pot process to prepare the key intermediate of the β -nucleoside compound, and the yield of the β -configuration substance increases significantly. The method has the advantages of a simple operation, saving energy and protecting the environment, and is suitable for industrial application. |
| priorityDate | 2016-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 203.