http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018106932-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c8cbbf2290b3f3a9988da29598baa2c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 |
| filingDate | 2017-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ed66b9d3a9d2545070e6cafbab6450c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80e2777440cb1d80a0857107dd75b428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b2efe24763e513344f3712bedd8d4f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db569281f042eb00058fb1eec21ba18b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4fdf7272e2bc346274eba6176c3b035 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d58091235564f88d4f613c352ad642af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3b583f99bae5dd20f894537082fdb65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5729bd2b5b47c5ba9c82201931af027d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a68e0bb55bb5abff1da82bc00f23fab0 |
| publicationDate | 2018-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2018106932-A2 |
| titleOfInvention | Compositions and methods for electronic control of gene expression |
| abstract | Provided are electrogenetic methods, devices and systems that use redox biomolecules to carry electronic information to engineered bacterial cells in order to control transcription from a synthetic gene circuit. A method includes providing electrical stimulation to one or more living cells, the cells comprising a promoter operably linked to a DNA segment, wherein the promoter is controllable by reversible redox dependent activation, whereby redox dependent activation and transcription of the DNA segment occurs. The promoter, the DNA segment, or both may be heterologous to the cell. The methods, devices and systems use single cell organisms, and can be prokaryotic or eukaryotic organisms. The DNA segment that is transcribed can encode a biologically active RNA polynucleotide that does not encode a protein, or it can encode a protein, which may or may not be secreted. Methods include modulating the electrical stimulation such that the redox dependent activation and transcription of the DNA transcription is altered. Methods and devices include supplying an electron acceptor to the cells, which results in a change in transcription, such as an increase in transcription. The electrical stimulation can change in response to a signal, such as the presence and/or amount of a biological molecule. Devices can be biologic-based sensors that contain living cells that are maintained in a housing capable of sustaining the cells. The devices are configured to provide electrical stimulation to the cells, and to change the electrical stimulation in response to signals. The devices can be implantable or wearable. Also provided is a system that contains a biologic-based sensor that includes a processor running software configured to adjust the electrical stimulation based on communication with a sensing component. |
| priorityDate | 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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