| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16043 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate |
2017-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_806ea866e6d152e621a87b2c9f7b466d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd5572d321a92ffa2c0fe3f421d86b9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0d22630585b8d8775388459a9c39ad3 |
| publicationDate |
2018-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018106724-A1 |
| titleOfInvention |
Optimized lentiviral vector for stem cell gene therapy of hemoglobinopathies |
| abstract |
In certain embodiments an optimized derivative of the CCLc-βAS3-FB lentiviral vector termed (CCLc-mGata/ANK-CoreLCR-βAS3-FB), is provided which is capable of driving lineage-restricted expression of a beta-globin gene ( e.g. , an anti-sickling β-globin like gene (βΑ83)). In certain embodiments the vectors described herein comprise novel defined LCR HS core sequences (HS2(~420 bp), HS3(~340 bp), HS4(~410 bp)) which can be used to replace the putative LCR HS sequences present within the "mini-LCR" (~3.6 kb reduced to ~1.2 kb) to produce an "optimized mini-LCR". |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110564770-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10961537-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3720509-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3931338-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110564770-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020168004-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022229223-A1 |
| priorityDate |
2016-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |