| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2817954cd008bcd609a4c4eb49050be |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B25-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B50-50 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B40-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B30-00 |
| filingDate |
2017-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b4ae90f42349ff06300ff05090ff601
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_519593ae469eb043bec6fcd2ea8c4f14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d90956a2ffdfdd1997fd68633ed60b2b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3746cf8a89c17a1a5f1120db5946541
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a88601b58c44fd8072c2a6fe23f52ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8c6b900f67bfc7040125edd250a18d7 |
| publicationDate |
2018-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018104385-A1 |
| titleOfInvention |
Codon optimization |
| abstract |
Method for determining an optimized nucleotide sequence encoding a predetermined amino acid sequence, wherein the nucleotide sequence is optimized for expression in a host cell, and wherein the method comprises the steps of: (a) generating a plurality of candidate nucleotide sequences encoding the predetermined amino acid sequence; (b) obtaining a sequence score based on a scoring function based on a plurality of sequence features that influence protein expression in the host cell using a statistical machine learning algorithm, wherein the plurality of sequence features comprises one or more sequence features selected from the group consisting of protein per time, average elongation rate and accuracy for each of the plurality of candidate nucleotide sequences of step (a); and (c) determining the candidate nucleotide sequence with optimized protein expression in the host cell as the optimized nucleotide sequence. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021226468-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112270956-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020069199-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112270956-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112513989-A |
| priorityDate |
2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |