| abstract |
This invention relates to methods of treating cancer in a subject in need thereof, e.g., in a human in need thereof, comprising determining determining the level of 5- Methylthioadenosine phosphorylase (MTAP) polynucleotide or polypeptide or the presence or absence of a mutation in MTAP in a sample from the human, and administering to the human an effective amount of a Type I protein arginine methyltransferase (Type I PRMT) inhibitor if the level of the MTAP polynucleotide or polypeptide is decreased relative to a reference or if a mutation in MTAP polynucleotide or polypeptide is present, thereby treating the cancer in the human. |