| abstract |
The present invention provides a combination of (i) an immune checkpoint modulator and (ii) a T-cell redirecting multifunctional antibody, or an antigen binding fragment thereof, for use in therapeutic treatment of a cancer disease. The T-cell redirecting multifunctional antibody comprises (a) a specificity against a T cell surface antigen; (b) a specificity against a cancer- and/or tumor-associated antigen; and (c) a binding site for human FcRI, FcyRlla and/or FcyRlll, wherein the antibody, or the antigen binding fragment thereof, binds with a higher affinity to human FcyRI, FcyRlla and/or FcyRlll than to human FcyRllb. |