| abstract |
Disclosed are isolated or purified antibodies, or antigen-binding fragments thereof, which specifically bind to one or both of MAGE-A3 and MAGE-A6 and does not bind to any one or more of MAGE-A1, MAGE-A2, MAGE-A4, MAGE-A5, MAGE-A8, MAGE-A9, MAGE-A10, MAGE-A11 and MAGE-A12. Related polypeptides, proteins, anti-MAGE-A3, and anti-MAGE-A6 binding moieties are also disclosed. Also disclosed are methods of assaying a biological sample for the presence of one or both of MAGE-A3 and MAGE-A6. Relating methods of diagnosing, treating, and prognosing cancer in a mammal are also disclosed. |