http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018095017-A1

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filingDate 2017-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6536b45aabe6444849db71b1203bf48c
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publicationDate 2018-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018095017-A1
titleOfInvention Targeted photothermal black phosphorus nano preparation and preparation method and application thereof
abstract A targeted photothermal black phosphorus nano preparation, comprising: a black phosphorus nano sheet, a polyethylene glycol adsorbed onto a surface of the black phosphorus nano sheet by electrostatic attraction, and a folic acid linked to the polyethylene glycol by an amide bond. One end of the polyethylene glycol is an amino group, and the other end is an imino group. A nitrogen atom of the imino group is linked to a carbonyl carbon atom of the folic acid to form the amide bond. The folic acid is disposed at an outermost layer of the nano preparation. Also disclosed is a preparation method of the targeted photothermal black phosphorus nano preparation and an application thereof for preparing a drug that treats cancer with targeted photothermal treatment at cellular levels.
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