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publicationDate 2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018094309-A2
titleOfInvention Fractal combination therapy
abstract Contemplated compositions and methods generate a durable immune synapse and so lead to activated T-cells and memory T-cell formation by use of selected co-stimulatory receptors and their ligands in conjunction with selected neoepitopes. Moreover, immune competent cells are attracted into a tumor microenvironment after activation of the T-cells using hybrid or chimeric binding proteins that comprise a chemokine portion and that target components of necrotic cells.
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