http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018086584-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac31afbea1cbbb03498644721ffb4a62 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 |
| filingDate | 2017-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87c33451cba89f78708f806b34240d19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d339f9e1400b743c41d44ae1217c07c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cf3a163fc3386626d0b93891aeaa9c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e117f56fecd9db4437b778aef3f1c13a |
| publicationDate | 2018-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2018086584-A1 |
| titleOfInvention | Aurkb small-molecule inhibitor and application thereof |
| abstract | Disclosed are an AURKB small-molecule inhibitor and the application thereof. Diindolylmethanes compounds represented by a general structure (I), stereoisomers, tautomerides, solvates, prodrugs, N-oxides, and pharmaceutically acceptable salts thereof: The present invention also protects application of the AURKB small-molecule inhibitor and modified derivatives thereof (the stereoisomers, tautomerides, solvates, prodrugs, N-oxides, and pharmaceutically acceptable salts thereof) in preparation of anti-tumor drugs. The AURKB kinase small-molecule inhibitor identified in the present invention is low in toxicity to normal cells and significantly inhibits the expression of a downstream gene E2F2 under the AURKB-mediated H3S10ph modification. Therefore, the AURKB small-molecule inhibitor can effectively inhibit the proliferation of various tumor cells and induce the apoptosis of tumor cells. Therefore, it is hopeful to develop the AURKB small-molecule inhibitor into a new anti-tumor drug. |
| priorityDate | 2016-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 152.