| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc8b706fb22ca0baba35f66ce3e501ef |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 |
| filingDate |
2017-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f6dd6bb1020d83fed86607264adf10e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66a39aaea498846082fe5275bfa5528c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2d5fd4ff22470953c9a344aece8b0e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c176754b7071138b415c32968aaa3a45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20e115c2e5466abebb01f0c6fa41fb2b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37769876d2081f13a1ed99f7801f047f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_daaced3b06b5a6147f62a517e38c03fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6412bc16a8d45e7033938fd7dc753e29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5dd49fc13ec7b270b08a013a89db7d3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57770412b8b0c191521a005ba8445505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b7e1f10dc8d1aa94c7643317cf9e113 |
| publicationDate |
2018-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018086546-A1 |
| titleOfInvention |
2-polysubstituted aromatic ring-pyrimidine derivative and preparation and medical use |
| abstract |
Provided are a 2-polysubstituted aromatic ring-pyrimidine derivative and an optical isomer thereof or a pharmaceutically acceptable salt or solvate thereof. The compound and the optical isomer thereof or the pharmaceutically acceptable salt or solvate thereof can be used in the preparation of an anti-tumor drug. The present invention uses the N-substituted pyridine-2-aminopyrimidine obtained through the structure-based virtual screening as a lead compound, designs and synthesizes a series of brand new small molecular Chk1 inhibitors, and tests the compounds for the Chk1 kinase inhibitory activity on a molecular level. The experiments confirm that the compound is a promising Chk1 inhibitor having strong anti-cancer effects and that the Chk1 kinase inhibitory activity and is a new drug for treating cancers, and can be used to treat solid tumours or leukemia associated with cell proliferation in humans or animals. The 2-polysubstituted aromatic ring-pyrimidine derivative provided by the present invention has the structure of general formula I: |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022162606-A1 |
| priorityDate |
2016-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |