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publicationDate 2018-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018078143-A1
titleOfInvention Means and methods for determining efficacy of anti-egfr inhibitors in colorectal cancer (crc) therapy
abstract The present invention relates to a method for determining the susceptibility/responsiveness of (a) cancer cell(s), preferably (a) colorectal cancer cell(s), to the treatment with an epidermal growth factor receptor (EGFR) inhibitor. Further, the present invention relates to a method of selecting (a) cell(s), (a) tissue(s) or (a) tumor sample(s) of colorectal cancer (CRC) with susceptibility to an epidermal growth factor receptor (EGFR) inhibitor. Furthermore, an in vitro method for the identification of a responder for or a subject, preferably a human patient, suffering from colorectal cancer (CRC) to an epidermal growth factor receptor (EGFR) inhibitor is disclosed. The present invention also relates to a method of monitoring the efficacy of a treatment of the colorectal cancer (CRC) with an epidermal growth factor receptor (EGFR) inhibitor.
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