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filingDate 2017-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72cb2ef273ecebafb95320a8f32c4fcb
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publicationDate 2018-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018076828-A1
titleOfInvention Afucosylated monoclonal antibody
abstract Provided is an afucosylated monoclonal antibody. The monoclonal antibody is a human IgG antibody and has an afucosylated carbohydrate structure at a heavy-chain carbohydrate binding site. Also provided are application of the monoclonal antibody in the preparation of antineoplastic drugs, and a composition containing the monoclonal antibody. Compared with a fucosylated monoclonal antibody, the provided afucosylated monoclonal antibody has higher biological activity in vitro and vivo and can be used for developing more effective therapeutic monoclonal antibody drugs.
priorityDate 2016-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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