| abstract |
The present invention relates to improved pharmaceutical formulations, uses and methods for the nasal delivery of peptide or protein drugs with advantageously high bioavailability, safety and cost-effectiveness. In particular, the invention provides a peptide or protein drug having a molecular weight of equal to or less than about 100 kDa for use as a medicament, wherein said peptide or protein drug is to be administered nasally in combination with a pharmaceutically acceptable copper salt/complex and/or a pharmaceutically acceptable zinc salt/complex and/or a pharmaceutically acceptable iron salt/complex. The invention also provides a pharmaceutical composition for use by nasal administration, comprising: a peptide or protein drug having a molecular weight of equal to or less than about 100 kDa; and a pharmaceutically acceptable copper salt/complex and/or a pharmaceutically acceptable zinc salt/complex and/or a pharmaceutically acceptable iron salt/complex. |