| abstract |
Compounds of formula (I), wherein Ar is an aryl group optionally further substituted with one or more groups R 3 ; A is a lipophilic, hydrophobic moiety; R 1 is a phosphodiester, phosphotriester, thioether or amide group; X is an unsubstituted or substituted C 6 to C 24 alkylene or alkenylene group, which is optionally interrupted by one or more -NR 9 -, -O- or -S- linkages, R 2 is -YC(R 4 )(R 5 )CO 2 R 6 ; and pharmaceutically acceptable salts or solvates thereof are useful as endosomolytic agents particularly for the delivery of nucleic acids useful in gene therapy. |