| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c7c6b46c3f886e76f7ae13540f485b5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-8813
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2513-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-84 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3616
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0676
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-095 |
| filingDate |
2017-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20145853e1cbc3bc037efc792ee32752 |
| publicationDate |
2019-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018044795-A9 |
| titleOfInvention |
COMPOSITIONS AND METHODS FOR PROGRAMMING ADULT CELLS WITH PLATELET-RICH BLOOD FRACTION CONTAINING WAFER-LIKE CELLS |
| abstract |
The present invention relates to a method for functional reprogramming of adult cells into an immature cell type that expresses one or more embryonic biomarkers. Reprogramming is accomplished by contacting adult cells with a platelet-rich fraction comprising platelet-like cells from umbilical cord blood or peripheral blood, and expanding the immature cell type in vitro under culture for producing a population of insulin-producing cells that express human beta cell-specific transcription factors and that are functionally equivalent to human pancreatic beta cells. Without being limited to a theory, platelet-like cells and their released mitochondria have markers associated with immune tolerance that can modulate the function and differentiation of immune cells. The present invention further relates to a pharmaceutical composition comprising a cell product containing a therapeutic amount of a population of insulin-producing cells derived from functionally reprogrammed adult cells, the population of insulin-producing cells expressing specific transcription factors. of human beta cells and being functionally equivalent to human pancreatic beta cells. |
| priorityDate |
2016-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |