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filingDate 2017-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e906d63b09a6bfac4110efe1d1b7ddd6
publicationDate 2018-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018042841-A1
titleOfInvention Method for producing same-containing material, and external agent, cosmetic and health food comprising same-containing liquid material
abstract A SAMe-containing material having a high SAMe content can be obtained by a method which comprises: a heating/dissolving step for supplying water and brown sugar to a culture tank and dissolving the brown sugar by heating; a culture step for supplying a yeast to the culture tank and culturing the same; a separation step for separating the yeast from the culture medium by centrifugation; a lysis treatment step for subjecting the obtained yeast to a lysis treatment and thus disrupting the yeast cells; and an extraction step for conducting extraction with water under acidic conditions. In the culture step, the culture is terminated at a timing from a point when the turbidity of the liquid culture medium changes from rise to fall to a point when the turbidity falls by 15%. The obtained SAMe-containing material in a liquid form is usable in an external agent, a cosmetic or a health food in a cream, gel or liquid state.
priorityDate 2016-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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