| abstract |
Embodiments of the invention relate to novel polymer bound guanosine-3 ', 5'-cyclic monophosphate (cGMP) multimers which modulate the cGMP signaling system, preferably having activating properties, and more preferably activators of cGMP-dependent protein kinase (PKG), and their related monomeric precursors. The invention also relates to related monomeric compounds, which may also exhibit modulating activity and / or may serve as multimeric monomer precursors. The invention further relates to the use of such compounds as reagents for signal transduction research and as modulators of binding proteins regulated by cyclic nucleotides and isoenzymes thereof, and as ligands for chromatography. affinity, for the production of antibodies or for diagnostic applications for example, on chip surfaces. |