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publicationDate 2018-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018037231-A1
titleOfInvention Methods of identifying microsatellite instability
abstract The present invention relates to methods and kits for identifying microsatellite instability (MSI) in a sample. In particular it relates to identifying microsatellite instability in a tumor sample, which may be from a subject suspected of having colorectal cancer or Lynch syndrome. The methods and kits can be used to identify mismatch repair defects. More particularly the invention relates to a panel of markers for a sequencing based MSI test, that can differentiate between MSI-H and MSS CRCs. The invention also allows for determination of biological significance, differentiating between PCR and sequencing errors and MSI induced indels/mutations.
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