http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018032796-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cea1c97de3e06b3a7459c47dbfa639e9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-22 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C61-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C61-15 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-00 |
| filingDate | 2017-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97b7bd7f35bcf95c7a332c907d999bbd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65e28ff3f724f08c9d6a1af0cf525b26 |
| publicationDate | 2018-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2018032796-A1 |
| titleOfInvention | Novel 2-fluorocyclopropane carboxylic acid synthesis method |
| abstract | Disclosed is a novel 2-fluorocyclopropane carboxylic acid synthesis method, comprising the following steps: 1) reacting 1,1-dichloro-1-fluoroethane with thiophenol in the presence of alkali to produce a phenyl sulfide intermediate; 2) carrying out an oxidization reaction on the phenyl sulfide intermediate and oxone; 3) carrying out an elimination reaction on a product obtained in step 2) in the presence of alkali to obtain 1-fluorine-1-phenylsulfonyl ethane; 4) carrying out an addition reaction on the 1-fluorine-1-phenylsulfonyl ethane and ethyl diazoacetate in the presence of a catalyst to obtain a cyclopropane intermediate; and 5) carrying out an elimination reaction on the cyclopropane intermediate in the presence of alkali, and then acidizing to obtain 2-fluorocyclopropane carboxylic acid. The synthetic route is short, the materials are bulk commodities, cheap and easy to get, oxone is used to replace a commonly used mCPBA agent, the process is safely amplified, the reaction yield is increased, the production cost is greatly lowered, and the operation is simple. |
| priorityDate | 2016-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 129.