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publicationDate 2018-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018032112-A1
titleOfInvention Microfluidic device
abstract A method and system for subtractive patterning of a substrate, which is utilized in the making of paper-based microfluidic analytical devices (pPADs). By adhering the substrate on an impermeable backing material, the substrate is etched to yield high resolution features, which can be utilized to construct MPADS capable of flowing and testing extremely small sample volumes. This system and method can be modified for various substrates to construct features for two and three dimensional flow systems. A substrate assembly is formed by affixing a substrate layer (e.g. paper) to an impermeable layer (e.g. foil). Portions of the substrate layer are cut away using an etching device to form one or more subtractive patterns on the substrate assembly the define fluid flow regions.
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