| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ffd5528fd07384d7b07ab484ed5b143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-507 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2017-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb40d3eee835dac596e84419e5760e67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07f769cbb7a5a67601e68a673b7eb367
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd051813bb71c49726eee2eba6279653
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af8aacc45485f8f97092059657395611 |
| publicationDate |
2018-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018005775-A1 |
| titleOfInvention |
Cd47 blockade enhances therapeutic activity of antibodies to low density cancer epitopes |
| abstract |
The present disclosure describes the use of monoclonal T Cell Receptor mimic (TCRm) antibodies (abs) in combination with CD47 blockade to kill tumor cells, reduce tumor burden and/or increase survival, particularly in acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML) or when the density of peptide epitopes from previously undruggable intracellular proteins presented in the context of major histocompatibility complex (MHC) molecules is lower than the density of typical antigenic targets of therapeutic antibodies to reduce solid and liquid tumors in a subject. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11591390-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3880215-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020102240-A1 |
| priorityDate |
2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |