| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f885ac21a0f093b8996a8f31ce04c122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_938bed369158a4954bbc5bbcb66c17b5 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y603-02021
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y603-02019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0695
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-104
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57438
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57446
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57423
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57426
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57434 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| filingDate |
2017-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc49fdf001043891c17613c6e2986e34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d72b77a5224082c3922afeeb3c3c1c27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dab4279de772d3b6f909ad8dbe4a88c |
| publicationDate |
2018-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018005378-A1 |
| titleOfInvention |
Method for detecting and isolating invasive cancer stem cells employing cell-surface amfr and the use thereof |
| abstract |
The present invention provides an invasive cancer stem cell (iCSC) or a substantively homogeneous cell population including said iCSC based on a cell-surface marker. The present invention further provides an invasive leukemia stem cell (iLSC) or a substantively homogeneous cell population including said iLSC based on a cell-surface marker. In particular, the present invention provides the detection and the isolation of said iCSC from an established solid tumor or said iLSC from an established hematopoietic cancer based on the expression of Autocrine Motility Factor Receptor (AMFR) on the cell surface in particular the surface of invadopodia. The present invention also provides a method of screening for pharmaceuticals using said iCSC or iLSC; a method or a kit of determining a diagnosis of aggressive solid tumor or hematopoietic cancer by employing cell-surface AMFR as a biomarker; an inhibiting agent of said iCSC or iLSC. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108226016-A |
| priorityDate |
2016-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |