| abstract |
[Problem] Provided are a method for producing 2-propanil 4-{(3S,5aR,6R,7R,8aS)-6-[(1E,3R)-4-(2,5-difluorophenoxy)-3-hydroxy-1-butene-1-yl]-7-hydroxyoctahydro-2H-cyclopenta[b]oxepine-3-yl}butanoate, which can solve various problems described in patent document 1, and a novel intermediate suitable for the production method. [Solution] According to the present invention, 2-propanil 4-{(3S,5aR,6R,7R,8aS)-6-[(1E,3R)-4-(2,5-difluorophenoxy)-3-hydroxy-1-butene-1-yl]-7-hydroxyoctahydro-2H-cyclopenta[b]oxepine-3-yl}butanoate can be stably supplied with a high total reaction yield by using a different starting material, and improving metathesis reaction, asymmetric reduction reaction, etc. |