| abstract |
The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1a) or a pharmaceutically acceptable salt thereof.n(In formula (1a), each of L 1 and L 2 independently represents an alkylene group having 3-10 carbon atoms; each of R 1 and R 2 independently represents an alkyl group having 4-22 carbon atoms or an alkenyl group having 4-22 carbon atoms; X 1 represents a single bond or -CO-O-; and ring P represents one of formulae (P-1) to (P-5).)n(In formulae (P-1) to (P-5), R 3 represents an alkyl group having 1-3 carbon atoms.) |