| abstract |
An antibody or antigen-binding portion thereof which binds to PSMA and comprises a heavy chain variable domain comprising the sequence given in SEQ ID NO:33, wherein SEQ ID NO:33 is: EVQLVQSGX 9 E X 11 KKPGASVKV SCKX 24 SGYTFT EYTIHWVX 38 QA X 41 GKGLEWIGN INPNX 55 GGTTY NOKFEDRX 68 TX 70 TVDKSTSTAY MELSSLRSED TAVYYCAAGW NFDYWGOGTT VTVSS wherein: X 9 is A or P X 11 is V or L X 24 is A or T X 38 is R or K X 41 is P or H X 55 is N or Q X 68 is V or A; and X 70 is I or L whereby the heavy chain variable domain comprises up to 3 amino acid sequence modification(s) between positions 1-30, 36-49, 67-98 and 105-115 of SEQ ID NO: 33. The invention also provides compounds that include the antibody or antigen-binding portion thereof, such as conjugates, and their use in the treatment or diagnosis of diseases, in particular cancers, particularly prostate cancer. |