http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017212018-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1271c5dc0f9289574052f5fa187c0fc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44fbe5b02d661b2a28cfb2187a78afce http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9f422ac028a4af49898a3d32e38e2008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d65c5f197cab1660172962c7a0c8b9d7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-10002 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
| filingDate | 2017-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc4741a664f6674075245c660455d5ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e4f7b8cace6b520a51f1db2a6edbcb2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2d9ef6083d1de0166c78d4d3e04dbbb |
| publicationDate | 2017-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2017212018-A1 |
| titleOfInvention | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
| abstract | The present invention relates to methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases. The Src-family kinase Fyn was the crucial effector for inhibition of SHP-1, while Lyn/Lck were required for its activation downstream of Fc, B-cell and T-cell antigen receptors. The inventors demonstrated that while Lyn-deficient mice aggravate inflammatory diseases, Fyn-deficient mice were protected. Similarly, they showed that subjects with lupus nephritis exhibited a Fyn-associated activatory signature, contrasting with a Lyn-associated inhibitory signature in healthy subjects. In particular, the present invention relates to a method of treating an autoimmune inflammatory disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a Fyn inhibitor. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3587416-A1 |
| priorityDate | 2016-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.