| abstract |
15β-substituted derivatives of estrone of general formula I wherein R 1 , R 2 , R 3 , R 4 , R 5 are independently selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 halogenalkyl, halogen, COOR 6 wherein R 6 is C 1 -C 4 alkyl; H, OH; optionally, R 3 , R 4 and R 5 are each formed by a hydrogen atom, while R1 and R2 together form an aryl group, preferably naphthyl; wherein the aromatic ring in position C-15 can be mono-, di-, tri-, tetra- and penta- substituted with substituents R 1 -R 5 . Compounds of the invention may be used for diagnosis and possibly also for the treatment of estrogen-dependent diseases. |