| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1875
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-58 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 |
| filingDate |
2017-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3e9085561b2ee810d01821f43923edc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69b8ea4c98f0e96d1b8097630173d1f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d0bba7977c05c5e8ce7a006e08277f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b369fb94aeed72bd0d922ee1d89b5579
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ed5dc8eb9a26cd5f6dc5f25d2b9fb64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4332d7bdc56c81b831895cc48d6df393
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67a2054213657334066b4d9d22eae690 |
| publicationDate |
2017-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017205541-A1 |
| titleOfInvention |
Growth-factor nanocapsules with tunable release capability for bone regeneration |
| abstract |
Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by short in vivo half-lives and a narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. A nanoscale controlled release system (degradable protein nanocapsule) is provided via in-situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes are achieved with the growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 (BMP-2) nanocapsules. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020139807-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020139800-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019137948-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019018383-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3508270-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021263070-A1 |
| priorityDate |
2016-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |