| abstract |
The present invention discloses a substituted quinoline compound as shown in formula (I), a pharmaceutical composition comprising said compound or a polymorph, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, an isotopic variant, a hydrate, or a solvate of same, and an application thereof. The substituted quinoline compound disclosed in the present invention and the pharmaceutical composition comprising said compound can act as a 5-HT 6 receptor antagonist, having good pharmacokinetic parameter characteristics, and being able to be used for preparing medicine for the treatment of Alzheimer's disease. |