| abstract |
The invention is directed to compositions and combinations of compositions comprising one or more C-C motif chemokine receptor 5 (CCR5) antagonists, one or more checkpoint antagonists and/or one or more FAK antagonists and for use in inducing an immune response to diseases, such as cancer or for use in the production of a medicament or medicaments for use in inducing an immune response to diseases, such as cancer or to treat cancer. The invention also provides methods of treating cancer with a combination of antagonists. The antagonists may be administered sequentially or substantially simultaneously to effectively initiate, enable, increase, enhance, or prolong the activity and/or number of immune cells, or beneficial response to a tumor. |