| abstract |
The invention is directed to a transdermal delivery device comprising a microneedle array and a reservoir portion, wherein said microneedles are composed of a swellable hydrogel polymer composition, the polymers being cross-linked polymers selected from at least one of the group consisting of poly(methylvinylether/maleic acid), esters thereof and poly(methyl/vinyl ether/maleic anhydride). The reservoir portion comprises at least one amphipathic component and at least one hydrophobic active agent, wherein in use, on insertion of the microneedles into the stratum corneum of skin, said microneedles swell and said amphipathic component and said at least one hydrophobic active agent diffuse down a concentration gradient from the reservoir layer via the microneedles into the skin. |