| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fb38ebd40c70e97cc5f1519c6699162 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7024
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7024
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-08 |
| filingDate |
2017-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b01a505ec5b42b965c92896b5dcdfd7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c78d6637b174675447c876cac2a39122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b5c3d395e6cf7e0df347fb4f188e807
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57944de6931ffa741cf572a3d2a81e8c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efcc8ef18983be4c5872c9c037d977d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54764fba670ee597196edb08e0be3df3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_833f16747e13c537ef5b971c1d96fdf2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3dc7bb57bbbf08ef29e611e17d29f5b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b0dd6bfec33a8022b36c1d25ba1b174 |
| publicationDate |
2017-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017185900-A1 |
| titleOfInvention |
Crocins compounds and uses thereof |
| abstract |
Provided are a series of crocins compounds and related pharmacological application thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis , as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H 2 O 2 ) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H 2 O 2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112552169-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112552169-B |
| priorityDate |
2016-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |