| abstract |
The present invention relates to a self-assembled nanostructure of block polypeptides based on elastin and resilin, having stimulus responsiveness and elasticity for drug delivery, tissue engineering and regenerative medicine, a preparation method thereof, and application thereof. It is observed that the diblock polypeptides form a self-assembled micelle structure capable of reversibly changing with temperature stimuli while hydrogel prepared using the triblock polypeptides performs reversible sol-gel or gel-sol transition with temperature stimuli and is improved in mechanical strength by chemical crosslinking among tyrosine residues. Having such excellent properties, the present invention may be used as a drug delivery carrier, a scaffold for tissue engineering, and a kit for tissue or organ regeneration. |