http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017153570-A3

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filingDate 2017-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46c2b8eebcdf7e7d461b8e4fe06ae21d
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publicationDate 2019-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2017153570-A3
titleOfInvention PH-SENSITIVE NUCLEIC POLY COMPLEXES
abstract The present invention relates to the field of small pH sensitive tools, in particular for measuring a pH value in biological media. I-patterned DNA structures have been widely used in the state of the art for the manufacture of nanodevices; however, assistance in folding a multi-stranded I-pattern, particularly at physiological pH, remains a challenge. The inventors have devised a pH-sensitive tool based on a multi-stranded I-pattern that comprises a complex of poly (nucleic acids) instead of the mono (nucleic acid) complexes that were known in the state of the art. The poly (nucleic acid) complex according to the invention is much easier to design and can be easily adapted according to the pH range of interest to be measured. The polynucleic complexes of the invention are useful for the design of various pH-sensitive devices and in particular pH biosensors and pH-sensitive delivery systems, particularly in the pharmaceutical field.
priorityDate 2016-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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