http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017147690-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab661f60bccbd929e702884082e89034 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02E50-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2402 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-14 |
| filingDate | 2017-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_739bf52eeca69796936d1aa0712a78ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fbcac39de10a958daa565c186efb5de |
| publicationDate | 2017-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2017147690-A1 |
| titleOfInvention | Engineered beta-glucosidases and methods of use thereof |
| abstract | A glycoside hydrolase family 3 (GH3) beta-glucosidase (BGL) polypeptide, comprising: (a) a GH3 BGL triosephosphateisomerase domain comprising a sequence as set forth in KGY 1 Y 2 Y 3 Y 4 LGP (SEQ ID NO: 251); (b) a GH3 BGL coordinating loop domain comprising a sequence as set forth in: GLDMX 1 MPX 2 X 3 X 4 X 5 X 6 X 7 X 8 X 9 X 19 X 11 X 12 X 13 X 14 X 15 X 16 (SEQ ID NO: 252), except that at least one of X 1t o X 16 , when present, is smaller than a corresponding reference amino acid residue in a corresponding GH3 BGL reference coordinating loop domain comprising a sequence as set forth in GLDMX 1ref MPX 2ref X 3ref X 4ref X 5ref X 6ref X 7ref X 8ref X 9ref X 19ref X 11ref X 12ref X 13ref X 14ref X 15ref X 16ref (SEQ ID NO: 252); (c) a GH3 BGL β/α sandwich domain comprising a sequence as set forth in: Z 1 Z 2 Z 3 Z 4 Z 5 Z 6 (SEQ ID NO: 253); and/or (d) a GH3 BGL β/α sandwich domain comprising a sequence as set forth in: A 1 A 2 A 3 A 4 A 5 (SEQ ID NO: 254) and a sequence as set forth in B 1 B 2 B 3 B 4 B 5 (SEQ ID NO: 255), with the proviso that the GH3 BGL polypeptide is not a polypeptide as set forth in any one of sequences of SEQ ID NOs: 22 to 44, and is not a secreted form of the polypeptide of any one of SEQ ID NOs: 22 to 44. The GH3 BGL has an improved resistance to substrate inhibition and/or product inhibition. It may be used in methods of converting biomass into a fermentable sugar. |
| priorityDate | 2016-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 301.