| abstract |
The present invention provides a compound represented by formula [I'], which has the effect of inhibiting an enzyme which produces 20-HETE, or a pharmaceutically acceptable salt thereof. (In formula [I']: the structure represented by formula [III] is any one of the structures represented by formulae [IV]; R 1 represents a hydrogen atom, a fluorine atom, methyl, etc.; R 2 , R 3 , and R 4 each independently represent a hydrogen atom, a fluorine atom, or methyl; W represents a single bond, C 1-3 alkanediyl, or formula -O-CH 2 CH 2 -; ring A represents (a) a substituted C 4-6 cycloalkyl, (b) a nitrogen atom-containing, substituted, 4- to 6-membered, and saturated heterocyclyl, (c) a substituted phenyl, (d) a substituted pyridyl, (e) a substituted 2,3-dihydrobenzofuran, (f) an oxygen atom-containing, 4- to 6-membered, and saturated heterocyclyl, etc.) |