http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017141024-A3

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filingDate 2017-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2017141024-A3
titleOfInvention Apparatus for measuring the concentration of target substances in blood
abstract A non-invasive testing apparatus for determining a concentration of a target substance, such as blood sugar, blood alcohol, cholesterol, etc., in a patient's blood involves applying an output RF signal (102) to the skin of a patient via an antenna (20), and measuring the amplitude and phase of a response signal, which is a function of the output RF signal (102) modified by an interaction with the patient's blood. Measurements are taken at different output RF frequencies (310), and the response (300) is plotted as a function of frequency (310). Various parameters (552, 554, 556, 550, 408, 410) are derived from the shape of the resulting plots, namely any or more of: a resonance frequency shift; a Q factor of the resonance; a group delay; a phase shift; an amplitude variation; a shape factor of the plot; and a gradient of the plot at different frequencies. Models of the derived parameters as a function of concentration of the target substance in blood are used to arrive at a determination of the latter. Further elements are a circuit (1000) for obtaining the amplitude and phase measurements, a calibration device (5008), a system (3000) for attaching the apparatus to the patient's body using a pulley belt, and an inflatable bladder system (4000) for ensuring proper sensor contact.
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