| abstract |
Provided are substituted steroids and a use thereof. In particular, the substituted steroids of the present invention are steroids as shown by formula (I), or a crystal form, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, a hydrate or a solvate thereof. The substituted steroids disclosed by the present invention and a composition containing the steroids have excellent inhibitory effects on the CYP17ase and androgen receptor (AR), and at the same time, have better pharmacokinetic parameter characteristics, and can improve the drug concentration of compounds in animals and thereby improve the therapeutic effect and safety of the drug. |