| abstract |
The present invention relates to an oral composite formulation comprising: a capsule containing a first drug with fat solubility; and a solid preparation containing a second drug, the solid preparation being inserted inside the capsule and including an oil repellent base coating layer on a surface thereof. The oral composite formulation of the present invention, which comprises a capsule containing a first drug with fat solubility and a solid preparation inserted inside the capsule, the solid preparation including an oil repellent base coating layer on a surface thereof and containing a second drug, allows a simultaneous administration of two types of ingredient drugs, and here, the oil repellent base coating layer on the surface can prevent an active ingredient of the solid preparation from being released by the first drug with fat solubility and causing side reactions with the first drug with fat solubility, thereby delivering two types of active ingredients independently to desired sites without loss of the active ingredients, respectively. |